A sphingosine kinase inhibitor combined with temozolomide induces glioblastoma cell death through accumulation of dihydrosphingosine and dihydroceramide, endoplasmic reticulum stress and autophagy

Glioblastomas (GBMs) are very aggressive tumors with low chemosensitivity. The DNA-alkylating agent temozolomide (TMZ) is currently the most efficient chemotoxic drug for GBM therapy; however, many patients develop resistance to TMZ. Combining TMZ with another agent could present an improved treatme...

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Bibliographic Details
Published in:Cell Death Dis
Main Authors: Noack, J, Choi, J, Richter, K, Kopp-Schneider, A, Régnier-Vigouroux, A
Format: Artigo
Language:Inglês
Published: Nature Publishing Group 2014
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Original Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4540206/
https://ncbi.nlm.nih.gov/pubmed/25255218
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/cddis.2014.384
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