Inhibition of Mitochondria- and Endoplasmic Reticulum Stress-Mediated Autophagy Augments Temozolomide-Induced Apoptosis in Glioma Cells

Autophagy is a crucial process for cells to maintain homeostasis and survival through degradation of cellular proteins and organelles, including mitochondria and endoplasmic reticula (ER). We previously demonstrated that temozolomide (TMZ), an alkylating agent for brain tumor chemotherapy, induced r...

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Bibliographic Details
Main Authors: Lin, Chien-Ju, Lee, Chin-Cheng, Shih, Yung-Luen, Lin, Chien-Huang, Wang, Sheng-Hao, Chen, Thay-Hsiung, Shih, Chwen-Ming
Format: Artigo
Language:Inglês
Published: Public Library of Science 2012
Subjects:
Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3382156/
https://ncbi.nlm.nih.gov/pubmed/22745676
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0038706
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