A sphingosine kinase inhibitor combined with temozolomide induces glioblastoma cell death through accumulation of dihydrosphingosine and dihydroceramide, endoplasmic reticulum stress and autophagy

Glioblastomas (GBMs) are very aggressive tumors with low chemosensitivity. The DNA-alkylating agent temozolomide (TMZ) is currently the most efficient chemotoxic drug for GBM therapy; however, many patients develop resistance to TMZ. Combining TMZ with another agent could present an improved treatme...

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Enregistré dans:
Détails bibliographiques
Publié dans:Cell Death Dis
Auteurs principaux: Noack, J, Choi, J, Richter, K, Kopp-Schneider, A, Régnier-Vigouroux, A
Format: Artigo
Langue:Inglês
Publié: Nature Publishing Group 2014
Sujets:
Original Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC4540206/
https://ncbi.nlm.nih.gov/pubmed/25255218
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/cddis.2014.384
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