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Microtubule motors transport phagosomes in the RPE, and lack of KLC1 leads to AMD-like pathogenesis
The degradation of phagosomes, derived from the ingestion of photoreceptor outer segment (POS) disk membranes, is a major role of the retinal pigment epithelium (RPE). Here, POS phagosomes were observed to associate with myosin-7a, and then kinesin-1, as they moved from the apical region of the RPE....
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| Publicado no: | J Cell Biol |
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| Main Authors: | , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
The Rockefeller University Press
2015
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4539993/ https://ncbi.nlm.nih.gov/pubmed/26261180 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1083/jcb.201410112 |
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