Defective phagosome motility and degradation in cell nonautonomous RPE pathogenesis of a dominant macular degeneration

Stargardt macular dystrophy 3 (STGD3) is caused by dominant mutations in the ELOVL4 gene. Like other macular degenerations, pathogenesis within the retinal pigment epithelium (RPE) appears to contribute to the loss of photoreceptors from the central retina. However, the RPE does not express ELOVL4,...

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Detalhes bibliográficos
Publicado no:Proc Natl Acad Sci U S A
Main Authors: Esteve-Rudd, Julian, Hazim, Roni A., Diemer, Tanja, Paniagua, Antonio E., Volland, Stefanie, Umapathy, Ankita, Williams, David S.
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2018
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6003516/
https://ncbi.nlm.nih.gov/pubmed/29735674
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1709211115
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