Mitochondrial and cytosolic roles of PINK1 shape induced regulatory T cell development and function

Mutations in PINK1, a serine/threonine kinase linked to familial early onset Parkinsonism, compromise mitochondrial integrity and metabolism and impair AKT signaling. As the activation of a naïve T cell requires an AKT-dependent reorganization of a cell’s metabolic machinery, we sought to determine...

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Bibliografiska uppgifter
I publikationen:Eur J Immunol
Huvudupphovsmän: Ellis, Gavin I., Zhi, Lianteng, Akundi, Ravi, Büeler, Hansruedi, Marti, Francesc
Materialtyp: Artigo
Språk:Inglês
Publicerad: 2013
Ämnen:
Article
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC4539263/
https://ncbi.nlm.nih.gov/pubmed/24037540
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/eji.201343571
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