Increased Mitochondrial Calcium Sensitivity and Abnormal Expression of Innate Immunity Genes Precede Dopaminergic Defects in Pink1-Deficient Mice

BACKGROUND: PTEN-induced kinase 1 (PINK1) is linked to recessive Parkinsonism (EOPD). Pink1 deletion results in impaired dopamine (DA) release and decreased mitochondrial respiration in the striatum of mice. To reveal additional mechanisms of Pink1-related dopaminergic dysfunction, we studied Ca(2+)...

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Detalhes bibliográficos
Main Authors: Akundi, Ravi S., Huang, Zhenyu, Eason, Joshua, Pandya, Jignesh D., Zhi, Lianteng, Cass, Wayne A., Sullivan, Patrick G., Büeler, Hansruedi
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2011
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Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3020954/
https://ncbi.nlm.nih.gov/pubmed/21249202
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0016038
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