CD1 Mouse Retina Is Shielded From Iron Overload Caused by a High Iron Diet

PURPOSE: High RPE iron levels have been associated with age-related macular degeneration. Mutation of the ferroxidase ceruloplasmin leads to RPE iron accumulation and degeneration in patients with aceruloplasminemia; mice lacking ceruloplasmin and its homolog hephaestin have a similar RPE degenerati...

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Detalles Bibliográficos
Publicado en:Invest Ophthalmol Vis Sci
Main Authors: Bhoiwala, Devang L., Song, Ying, Cwanger, Alyssa, Clark, Esther, Zhao, Liang-liang, Wang, Chenguang, Li, Yafeng, Song, Delu, Dunaief, Joshua L.
Formato: Artigo
Idioma:Inglês
Publicado: The Association for Research in Vision and Ophthalmology 2015
Assuntos:
Retinal Cell Biology
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC4539129/
https://ncbi.nlm.nih.gov/pubmed/26275132
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1167/iovs.15-17026
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