CD40-deficient mice generated by recombination-activating gene-2-deficient blastocyst complementation.

To study the role of B-cell antigen CD40 in immune responses, mouse embryonic stem (ES) cells in which both copies of the gene encoding CD40 had been disrupted by homologous recombination were injected in RAG-2 (recombination-activating gene-2)-deficient blastocysts to generate chimeras in which all...

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Autors principals: Castigli, E, Alt, F W, Davidson, L, Bottaro, A, Mizoguchi, E, Bhan, A K, Geha, R S
Format: Artigo
Idioma:Inglês
Publicat: 1994
Matèries:
Research Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC45391/
https://ncbi.nlm.nih.gov/pubmed/7527552
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