Self-tolerance to HLA focuses the response of immunized HLA-transgenic mice on production of antibody to precise polymorphic HLA alloantigens.

HLA class I-transgenic mice express HLA antigen on their tissues and establish self-tolerance to the expressed monomorphic and polymorphic determinants. When challenged with skin grafts and lymphoid cells of a second HLA-transgenic mouse expressing a different HLA molecule, a specific immune respons...

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Detalhes bibliográficos

Publicado no:	Proc Natl Acad Sci U S A
Principais autores:	Hämmerling, G J, Chamberlain, J W, Dill, O, Yang, S Y, Dupont, B, Khan, R, Chua, R, Weissman, S M, Hämmerling, U
Formato:	Artigo
Idioma:	Inglês
Publicado em:	National Academy of Sciences 1990
Assuntos:	Research Article
Acesso em linha:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC53236/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/2404277/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.87.1.235
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