Self-tolerance to HLA focuses the response of immunized HLA-transgenic mice on production of antibody to precise polymorphic HLA alloantigens.

HLA class I-transgenic mice express HLA antigen on their tissues and establish self-tolerance to the expressed monomorphic and polymorphic determinants. When challenged with skin grafts and lymphoid cells of a second HLA-transgenic mouse expressing a different HLA molecule, a specific immune respons...

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Main Authors: Hämmerling, G J, Chamberlain, J W, Dill, O, Yang, S Y, Dupont, B, Khan, R, Chua, R, Weissman, S M, Hämmerling, U
Format: Artigo
Sprog:Inglês
Udgivet: 1990
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC53236/
https://ncbi.nlm.nih.gov/pubmed/2404277
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