Paclitaxel targets FOXM1 to regulate KIF20A in mitotic catastrophe and breast cancer paclitaxel resistance

FOXM1 has been implicated in taxane resistance, but the molecular mechanism involved remains elusive. In here, we show that FOXM1 depletion can sensitize breast cancer cells and mouse embryonic fibroblasts into entering paclitaxel-induced senescence, with the loss of clonogenic ability, and the indu...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Veröffentlicht in:Oncogene
Hauptverfasser: Khongkow, P, Gomes, A R, Gong, C, Man, E P S, Tsang, J W-H, Zhao, F, Monteiro, L J, Coombes, R C, Medema, R H, Khoo, U S, Lam, E W-F
Format: Artigo
Sprache:Inglês
Veröffentlicht: Nature Publishing Group 2016
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Original Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4538879/
https://ncbi.nlm.nih.gov/pubmed/25961928
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/onc.2015.152
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