Paclitaxel targets FOXM1 to regulate KIF20A in mitotic catastrophe and breast cancer paclitaxel resistance

FOXM1 has been implicated in taxane resistance, but the molecular mechanism involved remains elusive. In here, we show that FOXM1 depletion can sensitize breast cancer cells and mouse embryonic fibroblasts into entering paclitaxel-induced senescence, with the loss of clonogenic ability, and the indu...

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Detalles Bibliográficos
Publicado en:Oncogene
Main Authors: Khongkow, P, Gomes, A R, Gong, C, Man, E P S, Tsang, J W-H, Zhao, F, Monteiro, L J, Coombes, R C, Medema, R H, Khoo, U S, Lam, E W-F
Formato: Artigo
Idioma:Inglês
Publicado: Nature Publishing Group 2016
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Original Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC4538879/
https://ncbi.nlm.nih.gov/pubmed/25961928
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/onc.2015.152
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