SUMOylation inhibits FOXM1 activity and delays mitotic transition

The forkhead box transcription factor FOXM1 is an essential effector of G2/M-phase transition, mitosis and the DNA damage response. As such, it is frequently deregulated during tumorigenesis. Here we report that FOXM1 is dynamically modified by SUMO1 but not by SUMO2/3 at multiple sites. We show tha...

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Main Authors: Myatt, S S, Kongsema, M, Man, C W-Y, Kelly, D J, Gomes, A R, Khongkow, P, Karunarathna, U, Zona, S, Langer, J K, Dunsby, C W, Coombes, R C, French, P M, Brosens, J J, Lam, E W-F
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group 2014
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Original Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4096495/
https://ncbi.nlm.nih.gov/pubmed/24362530
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/onc.2013.546
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