Gut microbiota facilitates dietary heme-induced epithelial hyperproliferation by opening the mucus barrier in colon

Colorectal cancer risk is associated with diets high in red meat. Heme, the pigment of red meat, induces cytotoxicity of colonic contents and elicits epithelial damage and compensatory hyperproliferation, leading to hyperplasia. Here we explore the possible causal role of the gut microbiota in heme-...

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Udgivet i:Proc Natl Acad Sci U S A
Main Authors: Ijssennagger, Noortje, Belzer, Clara, Hooiveld, Guido J., Dekker, Jan, van Mil, Saskia W. C., Müller, Michael, Kleerebezem, Michiel, van der Meer, Roelof
Format: Artigo
Sprog:Inglês
Udgivet: National Academy of Sciences 2015
Fag:
Biological Sciences
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4538683/
https://ncbi.nlm.nih.gov/pubmed/26216954
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1507645112
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