Dietary Heme-Mediated PPARα Activation Does Not Affect the Heme-Induced Epithelial Hyperproliferation and Hyperplasia in Mouse Colon

Red meat consumption is associated with an increased colon cancer risk. Heme, present in red meat, injures the colon surface epithelium by luminal cytotoxicity and reactive oxygen species. This surface injury is overcompensated by hyperproliferation and hyperplasia of crypt cells. Transcriptome anal...

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Hlavní autoři: IJssennagger, Noortje, de Wit, Nicole, Müller, Michael, van der Meer, Roelof
Médium: Artigo
Jazyk:Inglês
Vydáno: Public Library of Science 2012
Témata:
Research Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3419209/
https://ncbi.nlm.nih.gov/pubmed/22905243
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0043260
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