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Gut microbiota facilitates dietary heme-induced epithelial hyperproliferation by opening the mucus barrier in colon
Colorectal cancer risk is associated with diets high in red meat. Heme, the pigment of red meat, induces cytotoxicity of colonic contents and elicits epithelial damage and compensatory hyperproliferation, leading to hyperplasia. Here we explore the possible causal role of the gut microbiota in heme-...
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| Veröffentlicht in: | Proc Natl Acad Sci U S A |
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| Hauptverfasser: | , , , , , , , |
| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
National Academy of Sciences
2015
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4538683/ https://ncbi.nlm.nih.gov/pubmed/26216954 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1507645112 |
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