Gut microbiota facilitates dietary heme-induced epithelial hyperproliferation by opening the mucus barrier in colon

Colorectal cancer risk is associated with diets high in red meat. Heme, the pigment of red meat, induces cytotoxicity of colonic contents and elicits epithelial damage and compensatory hyperproliferation, leading to hyperplasia. Here we explore the possible causal role of the gut microbiota in heme-...

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Detalhes bibliográficos
Publicado no:Proc Natl Acad Sci U S A
Main Authors: Ijssennagger, Noortje, Belzer, Clara, Hooiveld, Guido J., Dekker, Jan, van Mil, Saskia W. C., Müller, Michael, Kleerebezem, Michiel, van der Meer, Roelof
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2015
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4538683/
https://ncbi.nlm.nih.gov/pubmed/26216954
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1507645112
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