Activation of the BMP-BMPR pathway conferred resistance to EGFR-TKIs in lung squamous cell carcinoma patients with EGFR mutations

The empirical criteria for defining a clinical subtype of lung cancer are gradually transiting from histopathology to genetic variations in driver genes. Targeting these driver mutations, such as sensitizing epidermal growth factor receptor (EGFR) mutations, has dramatically improved the prognosis o...

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Enregistré dans:
Détails bibliographiques
Publié dans:Proc Natl Acad Sci U S A
Auteurs principaux: Wang, Zhijie, Shen, Zhirong, Li, Zhenxiang, Duan, Jianchun, Fu, Shuai, Liu, Zhentao, Bai, Hua, Zhang, Zemin, Zhao, Jun, Wang, Xiaodong, Wang, Jie
Format: Artigo
Langue:Inglês
Publié: National Academy of Sciences 2015
Sujets:
Biological Sciences
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC4538677/
https://ncbi.nlm.nih.gov/pubmed/26216950
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1510837112
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