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Activation of the BMP-BMPR pathway conferred resistance to EGFR-TKIs in lung squamous cell carcinoma patients with EGFR mutations

The empirical criteria for defining a clinical subtype of lung cancer are gradually transiting from histopathology to genetic variations in driver genes. Targeting these driver mutations, such as sensitizing epidermal growth factor receptor (EGFR) mutations, has dramatically improved the prognosis o...

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Bibliografske podrobnosti
izdano v:Proc Natl Acad Sci U S A
Main Authors: Wang, Zhijie, Shen, Zhirong, Li, Zhenxiang, Duan, Jianchun, Fu, Shuai, Liu, Zhentao, Bai, Hua, Zhang, Zemin, Zhao, Jun, Wang, Xiaodong, Wang, Jie
Format: Artigo
Jezik:Inglês
Izdano: National Academy of Sciences 2015
Teme:
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC4538677/
https://ncbi.nlm.nih.gov/pubmed/26216950
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1510837112
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