Activation of the BMP-BMPR pathway conferred resistance to EGFR-TKIs in lung squamous cell carcinoma patients with EGFR mutations

The empirical criteria for defining a clinical subtype of lung cancer are gradually transiting from histopathology to genetic variations in driver genes. Targeting these driver mutations, such as sensitizing epidermal growth factor receptor (EGFR) mutations, has dramatically improved the prognosis o...

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Bibliographic Details
Published in:Proc Natl Acad Sci U S A
Main Authors: Wang, Zhijie, Shen, Zhirong, Li, Zhenxiang, Duan, Jianchun, Fu, Shuai, Liu, Zhentao, Bai, Hua, Zhang, Zemin, Zhao, Jun, Wang, Xiaodong, Wang, Jie
Format: Artigo
Language:Inglês
Published: National Academy of Sciences 2015
Subjects:
Biological Sciences
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4538677/
https://ncbi.nlm.nih.gov/pubmed/26216950
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1510837112
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