Activation of the BMP-BMPR pathway conferred resistance to EGFR-TKIs in lung squamous cell carcinoma patients with EGFR mutations

The empirical criteria for defining a clinical subtype of lung cancer are gradually transiting from histopathology to genetic variations in driver genes. Targeting these driver mutations, such as sensitizing epidermal growth factor receptor (EGFR) mutations, has dramatically improved the prognosis o...

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Detalhes bibliográficos
Publicado no:Proc Natl Acad Sci U S A
Main Authors: Wang, Zhijie, Shen, Zhirong, Li, Zhenxiang, Duan, Jianchun, Fu, Shuai, Liu, Zhentao, Bai, Hua, Zhang, Zemin, Zhao, Jun, Wang, Xiaodong, Wang, Jie
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2015
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4538677/
https://ncbi.nlm.nih.gov/pubmed/26216950
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1510837112
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