Effects of Klebsiella pneumoniae Carbapenemase Subtypes, Extended-Spectrum β-Lactamases, and Porin Mutations on the In Vitro Activity of Ceftazidime-Avibactam against Carbapenem-Resistant K. pneumoniae

Avibactam is a novel β-lactamase inhibitor with affinity for Klebsiella pneumoniae carbapenemases (KPCs). In combination with ceftazidime, the agent demonstrates activity against KPC-producing K. pneumoniae (KPC-Kp). KPC-Kp strains are genetically diverse and harbor multiple resistance determinants,...

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Detalles Bibliográficos
Publicado en:Antimicrob Agents Chemother
Main Authors: Shields, Ryan K., Clancy, Cornelius J., Hao, Binghua, Chen, Liang, Press, Ellen G., Iovine, Nicole M., Kreiswirth, Barry N., Nguyen, M. Hong
Formato: Artigo
Idioma:Inglês
Publicado: American Society for Microbiology 2015
Assuntos:
Mechanisms of Resistance
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC4538547/
https://ncbi.nlm.nih.gov/pubmed/26169413
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.00548-15
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