Population Pharmacokinetic Modeling of Itraconazole and Hydroxyitraconazole for Oral SUBA-Itraconazole and Sporanox Capsule Formulations in Healthy Subjects in Fed and Fasted States

Itraconazole is an orally active antifungal agent that has complex and highly variable absorption kinetics that is highly affected by food. This study aimed to develop a population pharmacokinetic model for itraconazole and the active metabolite hydroxyitraconazole, in particular, quantifying the ef...

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Detalhes bibliográficos
Publicado no:Antimicrob Agents Chemother
Main Authors: Abuhelwa, Ahmad Y., Foster, David J. R., Mudge, Stuart, Hayes, David, Upton, Richard N.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2015
Assuntos:
Pharmacology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4538523/
https://ncbi.nlm.nih.gov/pubmed/26149987
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.00973-15
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