Pharmacokinetics of Itraconazole and Hydroxyitraconazole in Healthy Subjects after Single and Multiple Doses of a Novel Formulation

Originally, itraconazole for parenteral administration was licensed in a 40% hydroxypropyl-beta-cyclodextrin (HPBCD) solution for intravenous administration. A novel formulation, the NanoCrystal formulation (NCF), was prepared. NCF consists of drug particles of approximately 200 to 300 nm. The pharm...

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Bibliographische Detailangaben
Hauptverfasser: Mouton, J. W., van Peer, A., de Beule, K., Van Vliet, A., Donnelly, J. P., Soons, P. A.
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Microbiology 2006
Schlagworte:
Pharmacology
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC1693991/
https://ncbi.nlm.nih.gov/pubmed/16982783
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.00630-06
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