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Styrylphenylphthalimides as Novel Transrepression-Selective Liver X Receptor (LXR) Modulators

[Image: see text] Anti-inflammatory effects of liver X receptor (LXR) ligands are thought to be largely due to LXR-mediated transrepression, whereas side effects are caused by activation of LXR-responsive gene expression (transactivation). Therefore, selective LXR modulators that preferentially exhi...

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Détails bibliographiques
Publié dans:ACS Med Chem Lett
Auteurs principaux: Nomura, Sayaka, Endo-Umeda, Kaori, Aoyama, Atsushi, Makishima, Makoto, Hashimoto, Yuichi, Ishikawa, Minoru
Format: Artigo
Langue:Inglês
Publié: American Chemical Society 2015
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC4538439/
https://ncbi.nlm.nih.gov/pubmed/26288691
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acsmedchemlett.5b00170
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