Synthesis and In Vitro Evaluation of Novel Liver X Receptor Agonists Based on Naphthoquinone Derivatives

We aimed to synthesize novel liver X receptor (LXR) agonists with potent agonist activity and subtype selectivity. Our synthetic scheme started with naphthoquinone derivatives, such as menadione and 2,3-dichloro-1,4-naphthoquinone. We introduced different substituents into the naphthoquinone structu...

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Publicado no:Molecules
Main Authors: Nishioka, Tatsuma, Endo-Umeda, Kaori, Ito, Yuki, Shimoda, Akane, Takeuchi, Atsuko, Tode, Chisato, Hirota, Yoshihisa, Osakabe, Naomi, Makishima, Makoto, Suhara, Yoshitomo
Formato: Artigo
Idioma:Inglês
Publicado em: MDPI 2019
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6930623/
https://ncbi.nlm.nih.gov/pubmed/31779181
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/molecules24234316
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