Should HFE p.C282Y homozygotes with moderately elevated serum ferritin be treated? A randomised controlled trial comparing iron reduction with sham treatment (Mi-iron)

INTRODUCTION: HFE p.C282Y homozygosity is the most common cause of hereditary haemochromatosis. There is currently insufficient evidence to assess whether non-specific symptoms or hepatic injury in homozygotes with moderately elevated iron defined as a serum ferritin (SF) of 300–1000 µg/L are relate...

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Publicado no:BMJ Open
Main Authors: Ong, Sim Yee, Dolling, Lara, Dixon, Jeannette L, Nicoll, Amanda J, Gurrin, Lyle C, Wolthuizen, Michelle, Wood, Erica M, Anderson, Greg J, Ramm, Grant A, Allen, Katrina J, Olynyk, John K, Crawford, Darrell, Kava, Jennifer, Ramm, Louise E, Gow, Paul, Durrant, Simon, Powell, Lawrie W, Delatycki, Martin B
Formato: Artigo
Idioma:Inglês
Publicado em: BMJ Publishing Group 2015
Assuntos:
Gastroenterology and Hepatology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4538285/
https://ncbi.nlm.nih.gov/pubmed/26270952
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1136/bmjopen-2015-008938
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