Phenotypic differences in viral immune escape explained by linking within-host dynamics to host-population immunity

Viruses that do not cause life-long immunity persist by evolving rapidly in response to prevailing host immunity. The immune-escape mutants emerge frequently, displacing or co-circulating with native strains even though mutations conferring immune evasion are often detrimental to viral replication....

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Udgivet i:J Theor Biol
Main Authors: Pepin, K.M., Volkov, I., Banavar, J.R., Wilke, C.O., Grenfell, B.T.
Format: Artigo
Sprog:Inglês
Udgivet: 2010
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4537168/
https://ncbi.nlm.nih.gov/pubmed/20570681
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jtbi.2010.05.036
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