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Loss of the deubiquitylase BAP1 alters class I histone deacetylase expression and sensitivity of mesothelioma cells to HDAC inhibitors

Histone deacetylases are important targets for cancer therapeutics, but their regulation is poorly understood. Our data show coordinated transcription of HDAC1 and HDAC2 in lung cancer cell lines, but suggest HDAC2 protein expression is cell-context specific. Through an unbiased siRNA screen we foun...

Deskribapen osoa

Gorde:
Xehetasun bibliografikoak
Argitaratua izan da:Oncotarget
Egile Nagusiak: Sacco, Joseph J., Kenyani, Jenna, Butt, Zohra, Carter, Rachel, Chew, Hui Yi, Cheeseman, Liam P., Darling, Sarah, Denny, Michael, Urbé, Sylvie, Clague, Michael J., Coulson, Judy M.
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: Impact Journals LLC 2015
Gaiak:
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC4537048/
https://ncbi.nlm.nih.gov/pubmed/25970771
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