By reducing hexokinase 2, resveratrol induces apoptosis in HCC cells addicted to aerobic glycolysis and inhibits tumor growth in mice

Cancer cells exhibit an altered metabolic phenotype known as the aerobic glycolysis. The expression of HK2 changes the metabolic phenotype of cells to support cancerous growth. In the present study, we investigated the inhibitory effect of resveratrol on HK2 expression and hepatocellular carcinoma (...

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Detalhes bibliográficos
Publicado no:Oncotarget
Main Authors: Dai, Weiqi, Wang, Fan, Lu, Jie, Xia, Yujing, He, Lei, Chen, Kan, Li, Jingjing, Li, Sainan, Liu, Tong, Zheng, Yuanyuan, Wang, Jianrong, Lu, Wenxia, Zhou, Yuqing, Yin, Qin, Abudumijiti, Huerxidan, Chen, Rongxia, Zhang, Rong, Zhou, Li, Zhou, Zheng, Zhu, Rong, Yang, Jing, Wang, Chengfen, Zhang, Huawei, Zhou, Yingqun, Xu, Ling, Guo, Chuanyong
Formato: Artigo
Idioma:Inglês
Publicado em: Impact Journals LLC 2015
Assuntos:
Research Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4537043/
https://ncbi.nlm.nih.gov/pubmed/25938543
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