By reducing hexokinase 2, resveratrol induces apoptosis in HCC cells addicted to aerobic glycolysis and inhibits tumor growth in mice

Cancer cells exhibit an altered metabolic phenotype known as the aerobic glycolysis. The expression of HK2 changes the metabolic phenotype of cells to support cancerous growth. In the present study, we investigated the inhibitory effect of resveratrol on HK2 expression and hepatocellular carcinoma (...

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Vydáno v:Oncotarget
Hlavní autoři: Dai, Weiqi, Wang, Fan, Lu, Jie, Xia, Yujing, He, Lei, Chen, Kan, Li, Jingjing, Li, Sainan, Liu, Tong, Zheng, Yuanyuan, Wang, Jianrong, Lu, Wenxia, Zhou, Yuqing, Yin, Qin, Abudumijiti, Huerxidan, Chen, Rongxia, Zhang, Rong, Zhou, Li, Zhou, Zheng, Zhu, Rong, Yang, Jing, Wang, Chengfen, Zhang, Huawei, Zhou, Yingqun, Xu, Ling, Guo, Chuanyong
Médium: Artigo
Jazyk:Inglês
Vydáno: Impact Journals LLC 2015
Témata:
Research Paper
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4537043/
https://ncbi.nlm.nih.gov/pubmed/25938543
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