Protein Kinase A-induced tamoxifen resistance is mediated by anchoring protein AKAP13

BACKGROUND: Estrogen Receptor alpha (ERα)-positive breast cancer patients receive endocrine therapy, often in the form of tamoxifen. However, resistance to tamoxifen is frequently observed. A signalling cascade that leads to tamoxifen resistance is dictated by activation of the Protein Kinase A (PKA...

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Publicat a:BMC Cancer
Autors principals: Bentin Toaldo, Cristiane, Alexi, Xanthippi, Beelen, Karin, Kok, Marleen, Hauptmann, Michael, Jansen, Maurice, Berns, Els, Neefjes, Jacques, Linn, Sabine, Michalides, Rob, Zwart, Wilbert
Format: Artigo
Idioma:Inglês
Publicat: BioMed Central 2015
Matèries:
Research Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4536754/
https://ncbi.nlm.nih.gov/pubmed/26272591
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12885-015-1591-4
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