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PKA-induced resistance to tamoxifen is associated with an altered orientation of ERα towards co-activator SRC-1
Resistance to tamoxifen is observed in half of the recurrences in breast cancer, where the anti-estrogen tamoxifen acquires agonistic properties for transactivating estrogen receptor α (ERα). In a previous study, we showed that protein kinase A (PKA)-mediated phosphorylation of serine 305 (S305) of...
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| Hauptverfasser: | , , , , , , , |
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| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
Nature Publishing Group
2007
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1949008/ https://ncbi.nlm.nih.gov/pubmed/17627277 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.emboj.7601791 |
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