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PKA-induced resistance to tamoxifen is associated with an altered orientation of ERα towards co-activator SRC-1

Resistance to tamoxifen is observed in half of the recurrences in breast cancer, where the anti-estrogen tamoxifen acquires agonistic properties for transactivating estrogen receptor α (ERα). In a previous study, we showed that protein kinase A (PKA)-mediated phosphorylation of serine 305 (S305) of...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: Zwart, Wilbert, Griekspoor, Alexander, Berno, Valeria, Lakeman, Kim, Jalink, Kees, Mancini, Michael, Neefjes, Jacques, Michalides, Rob
Format: Artigo
Sprache:Inglês
Veröffentlicht: Nature Publishing Group 2007
Schlagworte:
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC1949008/
https://ncbi.nlm.nih.gov/pubmed/17627277
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.emboj.7601791
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