Adenylyl Cyclase Anchoring by a Kinase Anchor Protein AKAP5 (AKAP79/150) Is Important for Postsynaptic β-Adrenergic Signaling

Recent evidence indicates that the A kinase anchor protein AKAP5 (AKAP79/150) interacts not only with PKA but also with various adenylyl cyclase (AC) isoforms. However, the physiological relevance of AC-AKAP5 binding is largely unexplored. We now show that postsynaptic targeting of AC by AKAP5 is im...

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Hlavní autoři: Zhang, Mingxu, Patriarchi, Tommaso, Stein, Ivar S., Qian, Hai, Matt, Lucas, Nguyen, Minh, Xiang, Yang K., Hell, Johannes W.
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Biochemistry and Molecular Biology 2013
Témata:
Neurobiology
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3682589/
https://ncbi.nlm.nih.gov/pubmed/23649627
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M112.449462
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