The Solution Structure and Dynamics of Full-length Human Cerebral Dopamine Neurotrophic Factor and Its Neuroprotective Role against α-Synuclein Oligomers

Cerebral dopamine neurotrophic factor (CDNF) is a promising therapeutic agent for Parkinson disease. As such, there has been great interest in studying its mode of action, which remains unknown. The three-dimensional crystal structure of the N terminus (residues 9–107) of CDNF has been determined, b...

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Vydáno v:J Biol Chem
Hlavní autoři: Latge, Cristiane, Cabral, Katia M. S., de Oliveira, Guilherme A. P., Raymundo, Diana P., Freitas, Julia A., Johanson, Laizes, Romão, Luciana F., Palhano, Fernando L., Herrmann, Torsten, Almeida, Marcius S., Foguel, Debora
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Biochemistry and Molecular Biology 2015
Témata:
Protein Structure and Folding
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4536457/
https://ncbi.nlm.nih.gov/pubmed/26149686
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M115.662254
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