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Cytochrome P450 3A Enzymes Catalyze the O(6)-Demethylation of Thebaine, a Key Step in Endogenous Mammalian Morphine Biosynthesis
Morphine, first characterized in opium from the poppy Papaver somniferum, is one of the strongest known analgesics. Endogenous morphine has been identified in several mammalian cells and tissues. The synthetic pathway of morphine in the opium poppy has been elucidated. The presence of common interme...
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| Pubblicato in: | J Biol Chem |
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| Autori principali: | , , , |
| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
American Society for Biochemistry and Molecular Biology
2015
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4536429/ https://ncbi.nlm.nih.gov/pubmed/26157146 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M115.665331 |
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