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Traveling two diverging roads, cytochrome-P450 catalyzed demethylation and γ-lactone formation in bacterial gibberellin biosynthesis

Biosynthesis of the gibberellin plant hormones evolved independently in plants and microbes, but the pathways proceed via similar transformations. The combined demethylation and γ-lactone ring forming transformation is of significant mechanistic interest, yet remains opaque. The relevant CYP112 from...

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Detalhes bibliográficos
Publicado no:Angew Chem Int Ed Engl
Main Authors: Nagel, Raimund, Peters, Reuben J.
Formato: Artigo
Idioma:Inglês
Publicado em: 2018
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6020689/
https://ncbi.nlm.nih.gov/pubmed/29517843
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/anie.201713403
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