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Mammalian Cytochrome P450 Enzymes Catalyze the Phenol-coupling Step in Endogenous Morphine Biosynthesis

A cytochrome P450 (P450) enzyme in porcine liver that catalyzed the phenol-coupling reaction of the substrate (R)-reticuline to salutaridine was previously purified to homogeneity (Amann, T., Roos, P. H., Huh, H., and Zenk, M. H. (1995) Heterocycles 40, 425–440). This reaction was found to be cataly...

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Detalhes bibliográficos
Main Authors: Grobe, Nadja, Zhang, Baichen, Fisinger, Ursula, Kutchan, Toni M., Zenk, Meinhart H., Guengerich, F. Peter
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2009
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2782035/
https://ncbi.nlm.nih.gov/pubmed/19561069
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M109.011320
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