Modeling Ligand Recognition at the P2Y(12) Receptor in Light of X-Ray Structural Information

The G protein-coupled P2Y(12) receptor (P2Y(12)R) is an important antithrombotic target and of great interest for pharmaceutical discovery. Its recently solved, highly divergent crystallographic structures in complex either with nucleotides (full or partial agonist) or with a nonnucleotide antagonis...

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Detalhes bibliográficos
Publicado no:J Comput Aided Mol Des
Main Authors: Paoletta, Silvia, Sabbadin, Davide, von Kügelgen, Ivar, Hinz, Sonja, Katritch, Vsevolod, Hoffmann, Kristina, Abdelrahman, Aliaa, Straßburger, Jens, Baqi, Younis, Zhao, Qiang, Stevens, Raymond C., Moro, Stefano, Müller, Christa E., Jacobson, Kenneth A.
Formato: Artigo
Idioma:Inglês
Publicado em: 2015
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4536181/
https://ncbi.nlm.nih.gov/pubmed/26194851
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s10822-015-9858-z
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