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The group II metabotropic glutamate receptor agonist LY379268 reduces toluene-induced enhancement of brain-stimulation reward and behavioral disturbances

Toluene, a widely abused solvent with demonstrated addictive potential in humans, has been reported to negatively modulate N-methyl-D-aspartate receptors (NMDARs) and alter glutamatergic neurotransmission. The group II metabotropic glutamate receptor (mGluR) agonist LY379268 has been shown to regula...

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Detalhes bibliográficos
Publicado no:Psychopharmacology (Berl)
Main Authors: Chan, Ming-Huan, Tsai, Yi-Ling, Lee, Mei-Yi, Stoker, Astrid K., Markou, Athina, Chen, Hwei-Hsien
Formato: Artigo
Idioma:Inglês
Publicado em: 2015
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4536139/
https://ncbi.nlm.nih.gov/pubmed/26044619
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00213-015-3973-3
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