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The glutamatergic compounds sarcosine and N-acetylcysteine ameliorate prepulse inhibition deficits in metabotropic glutamate 5 receptor knockout mice

RATIONALE: Mice lacking metabotropic glutamate receptors 5 (mGluR5) exhibit reduced glutamatergic function and behavioral abnormalities, including deficits in prepulse inhibition (PPI) of the startle response that may be relevant to schizophrenia. Thus, these mice are an animal model that may be use...

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Autors principals: Chen, Hwei-Hsien, Stoker, Astrid, Markou, Athina
Format: Artigo
Idioma:Inglês
Publicat: Springer-Verlag 2010
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2855017/
https://ncbi.nlm.nih.gov/pubmed/20217053
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00213-010-1802-2
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