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Chromothripsis and focal copy number alterations determine poor outcome in malignant melanoma

Genetic changes during tumorigenesis are usually acquired sequentially. However, a recent study showed that in 2 to 3% of all cancers a single catastrophic event, termed chromothripsis, can lead to massive genomic rearrangements confined to one or a few chromosomes. In order to explore whether the d...

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Detalhes bibliográficos
Publicado no:Cancer Res
Main Authors: Hirsch, Daniela, Kemmerling, Ralf, Davis, Sean, Camps, Jordi, Meltzer, Paul S., Ried, Thomas, Gaiser, Timo
Formato: Artigo
Idioma:Inglês
Publicado em: 2012
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4535704/
https://ncbi.nlm.nih.gov/pubmed/23271725
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-12-0928
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