Application of a BRAF Pyrosequencing Assay for Mutation Detection and Copy Number Analysis in Malignant Melanoma

Mutations in the BRAF gene are found in the majority of cutaneous malignant melanomas and subsets of other tumors. These mutations lead to constitutive activation of BRAF with increased downstream ERK (extracellular signal-regulated kinase) signaling; therefore, the development of RAF kinase inhibit...

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Hlavní autoři: Spittle, Cynthia, Ward, M. Renee, Nathanson, Katherine L., Gimotty, Phyllis A., Rappaport, Eric, Brose, Marcia S., Medina, Angelica, Letrero, Richard, Herlyn, Meenhard, Edwards, Robin H.
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Investigative Pathology 2007
Témata:
Regular Articles
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC1975103/
https://ncbi.nlm.nih.gov/pubmed/17690212
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2353/jmoldx.2007.060191
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