Application of a BRAF Pyrosequencing Assay for Mutation Detection and Copy Number Analysis in Malignant Melanoma

Mutations in the BRAF gene are found in the majority of cutaneous malignant melanomas and subsets of other tumors. These mutations lead to constitutive activation of BRAF with increased downstream ERK (extracellular signal-regulated kinase) signaling; therefore, the development of RAF kinase inhibit...

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Detalhes bibliográficos
Main Authors: Spittle, Cynthia, Ward, M. Renee, Nathanson, Katherine L., Gimotty, Phyllis A., Rappaport, Eric, Brose, Marcia S., Medina, Angelica, Letrero, Richard, Herlyn, Meenhard, Edwards, Robin H.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Investigative Pathology 2007
Assuntos:
Regular Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1975103/
https://ncbi.nlm.nih.gov/pubmed/17690212
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2353/jmoldx.2007.060191
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