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Reprogramming immune response with capsid-optimized AAV6 vectors for immunotherapy of cancer
In the current studies we generated novel capsid-optimized AAV serotype 6 (AAV6) vectors expressing a tumor-associated antigen, and assessed their ability to activate a protective T-cell response in an animal model. First, we showed that specific mutations in the AAV6 capsid increase the transductio...
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| Опубликовано в: : | J Immunother |
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| Главные авторы: | , , , , |
| Формат: | Artigo |
| Язык: | Inglês |
| Опубликовано: |
2015
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| Предметы: | |
| Online-ссылка: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4535186/ https://ncbi.nlm.nih.gov/pubmed/26261893 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1097/CJI.0000000000000093 |
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