Development of Polypeptide-based Nanoparticles for Non-viral Delivery of CD22 RNA Trans-splicing Molecule as a New Precision Medicine Candidate Against B-lineage ALL

CD22ΔE12 has emerged as a driver lesion in the pathogenesis of pediatric B-lineage acute lymphoblastic leukemia (ALL) and a new molecular target for RNA therapeutics. Here we report a 43-gene CD22ΔE12 signature transcriptome that shows a striking representation in primary human leukemia cells from p...

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Detalhes bibliográficos
Publicado no:EBioMedicine
Main Authors: Uckun, Fatih M., Mitchell, Lloyd G., Qazi, Sanjive, Liu, Yang, Zheng, Nan, Myers, Dorothea E., Song, Ziyuan, Ma, Hong, Cheng, Jianjun
Formato: Artigo
Idioma:Inglês
Publicado em: Elsevier 2015
Assuntos:
Original Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4534679/
https://ncbi.nlm.nih.gov/pubmed/26288837
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ebiom.2015.04.016
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