Small-molecule enhancers of autophagy modulate cellular disease phenotypes suggested by human genetics

Studies of human genetics and pathophysiology have implicated the regulation of autophagy in inflammation, neurodegeneration, infection, and autoimmunity. These findings have motivated the use of small-molecule probes to study how modulation of autophagy affects disease-associated phenotypes. Here,...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:Proc Natl Acad Sci U S A
Prif Awduron: Kuo, Szu-Yu, Castoreno, Adam B., Aldrich, Leslie N., Lassen, Kara G., Goel, Gautam, Dančík, Vlado, Kuballa, Petric, Latorre, Isabel, Conway, Kara L., Sarkar, Sovan, Maetzel, Dorothea, Jaenisch, Rudolf, Clemons, Paul A., Schreiber, Stuart L., Shamji, Alykhan F., Xavier, Ramnik J.
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: National Academy of Sciences 2015
Pynciau:
PNAS Plus
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC4534235/
https://ncbi.nlm.nih.gov/pubmed/26195741
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1512289112
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