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Restarting stalled autophagy a potential therapeutic approach for the lipid storage disorder, Niemann-Pick type C1 disease

Autophagy is essential for cellular homeostasis and its dysfunction in human diseases has been implicated in the accumulation of misfolded protein and in cellular toxicity. We have recently shown impairment in autophagic flux in the lipid storage disorder, Niemann-Pick type C1 (NPC1) disease associa...

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Bibliografiske detaljer
Main Authors: Sarkar, Sovan, Maetzel, Dorothea, Korolchuk, Viktor I, Jaenisch, Rudolf
Format: Artigo
Sprog:Inglês
Udgivet: Landes Bioscience 2014
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4091173/
https://ncbi.nlm.nih.gov/pubmed/24879158
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4161/auto.28623
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