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Restarting stalled autophagy a potential therapeutic approach for the lipid storage disorder, Niemann-Pick type C1 disease

Autophagy is essential for cellular homeostasis and its dysfunction in human diseases has been implicated in the accumulation of misfolded protein and in cellular toxicity. We have recently shown impairment in autophagic flux in the lipid storage disorder, Niemann-Pick type C1 (NPC1) disease associa...

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Sonraí Bibleagrafaíochta
Main Authors: Sarkar, Sovan, Maetzel, Dorothea, Korolchuk, Viktor I, Jaenisch, Rudolf
Formáid: Artigo
Teanga:Inglês
Foilsithe: Landes Bioscience 2014
Ábhair:
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC4091173/
https://ncbi.nlm.nih.gov/pubmed/24879158
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4161/auto.28623
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