Impaired autophagy in the lipid storage disorder Niemann–Pick type C1 disease

Autophagy dysfunction has been implicated in misfolded protein accumulation and cellular toxicity in several diseases. Whether alterations in autophagy also contribute to the pathology of lipid storage disorders is not clear. Here we show defective autophagy in Niemann-Pick type C1 (NPC1) disease as...

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Autores principales: Sarkar, Sovan, Carroll, Bernadette, Buganim, Yosef, Maetzel, Dorothea, Ng, Alex H.M., Cassady, John, Cohen, Malkiel, Chakraborty, Souvik, Wang, Haoyi, Spooner, Eric, Ploegh, Hidde, Gsponer, Joerg, Korolchuk, Viktor I., Jaenisch, Rudolf
Formato: Artigo
Lenguaje:Inglês
Publicado: 2013
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC3957429/
https://ncbi.nlm.nih.gov/pubmed/24290752
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2013.10.042
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