BACE1 Activity Is Modulated by Cell-Associated Sphingosine-1-Phosphate

Sphingosine kinase (SphK) 1 and 2 phosphorylate sphingosine to generate sphingosine-1-phosphate (S1P), a pluripotent lipophilic mediator implicated in a variety of cellular events. Here we show that the activity of β-site APP cleaving enzyme-1 (BACE1), the rate-limiting enzyme for amyloid-β peptide...

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Bibliografiske detaljer
Udgivet i:J Neurosci
Main Authors: Takasugi, Nobumasa, Sasaki, Tomoki, Suzuki, Kunimichi, Osawa, Satoko, Isshiki, Hayato, Hori, Yukiko, Shimada, Naoaki, Higo, Takuya, Yokoshima, Satoshi, Fukuyama, Tohru, Lee, Virginia M.-Y., Trojanowski, John Q., Tomita, Taisuke, Iwatsubo, Takeshi
Format: Artigo
Sprog:Inglês
Udgivet: Society for Neuroscience 2011
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Articles
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4534000/
https://ncbi.nlm.nih.gov/pubmed/21543615
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.6467-10.2011
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