SHMT2 drives glioma cell survival in the tumor microenvironment but imposes a dependence on glycine clearance

Cancer cells adapt their metabolic processes to support rapid proliferation, but less is known about how cancer cells alter metabolism to promote cell survival in a poorly vascularized tumor microenvironment(1–3). Here, we identify a key role for serine and glycine metabolism in the survival of brai...

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發表在:Nature
Main Authors: Kim, Dohoon, Fiske, Brian P., Birsoy, Kivanc, Freinkman, Elizaveta, Kami, Kenjiro, Possemato, Richard, Chudnovsky, Yakov, Pacold, Michael E., Chen, Walter W., Cantor, Jason R., Shelton, Laura M., Gui, Dan Y., Kwon, Manjae, Ramkissoon, Shakti H., Ligon, Keith L., Kang, Seong Woo, Snuderl, Matija, Heiden, Matthew G. Vander, Sabatini, David M.
格式: Artigo
語言:Inglês
出版: 2015
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在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC4533874/
https://ncbi.nlm.nih.gov/pubmed/25855294
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nature14363
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