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Crystal structure of R-spondin 2 in complex with the ectodomains of its receptors LGR5 and ZNRF3()

The four secreted R-spondin (Rspo1-4) proteins of vertebrates function as stem cell growth factors and potentiate canonical Wnt signalling. Rspo proteins act by cross-linking members of two cell surface receptor families, complexing the stem cell markers LGR4-6 with the Frizzled-specific E3 ubiquiti...

詳細記述

保存先:
書誌詳細
出版年:J Struct Biol
主要な著者: Zebisch, Matthias, Jones, E. Yvonne
フォーマット: Artigo
言語:Inglês
出版事項: Academic Press 2015
主題:
オンライン・アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC4533229/
https://ncbi.nlm.nih.gov/pubmed/26123262
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jsb.2015.05.008
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